TBI results in hormone disruption in 25-69% of those effected. The major cause is a pituitary/neuro-endocrine effect. This has been described since the early 20th century.
High rate (78%) of those post TBI have low cortisol levels due to damaged HPA axis. Low cortisol levels post TBI are associated with an increase mortality rate and increased long-term HPA disruption.
Numerous in vivo and in vitro studies confirm that HBOT induces neurogenesis
HIF-1α is the principal mediator of cellular hypoxia adaptations
activated by hypoxia, HIF-1α causes the transcription of its regulated downstream genes, including erythropoietin (EPO) and VEGF which are known to promote neurogenesis
The safety of HBOT was also evaluated and it was pointed out that, if given at proper paradigms, like 1.5 ATA for 60 minutes, HBOT will not cause oxygen toxicity
Rockswold et al., on the other hand, found that HBOT might be potentially beneficial for severe TBI patients
McDonagh et al., concluded that there was insufficient evidence to establish the effectiveness of HBOT in the treatment of TBI
The first multicenter, randomized, double-blind, controlled trial in 2009 found that 40-hour HBOT of 24% oxygen at 1.3 ATM produced significant improvement in children's overall functioning, receptive language, social interaction, eye contact, and sensory/cognitive awareness compared to those received slightly pressurized room air
Another study in 2010 on 16 autism patients, adopting a similar treatment paradigm, showed no effect on a wide array of behavioral evaluations
To date, there is little evidence that HBOT causes malignant growth or metastasis. A history of malignancy should therefore not be considered as a contraindication for HBOT
HBOT enhances the production of reactive oxygen species (ROS) and causes oxidative stress in body tissues
Excessive accumulation of oxidative stress may contribute to neurodegenerative processes and cell death in the brain, as seen in diseases like Alzheimer's disease (AD) and Parkinson's disease (PD)
Hormesis
process that results in a functional improvement of cellular stress resistance, survival, and longevity in response to sub-lethal levels of stress
Animal model shows that n-3 intake reduced axonal injury after injury insult. This implies a use in n-3 intake even after an insult has occured. This implies a role for n-3 in neuroplasticity.
Tynor Weight Cuff
Tynor Weight cuffs are used to exercise ailing joints to build strength and aid recovery. Tynor Weight Cuff is flexible and cushion, so it does not injure. Recommended for use to improve muscle tone, muscle mass, strength and stamina.
Tynor Weight Cuff Features
Offers 1 kg resistance when wrapped around
Weight is wrapped in comfortable and soft fabric
Used to build muscles, flexibility or to lose weight
Can be secured easily around to prevent injuries or accidents
Cuff is safe to be used during everyday activities as well
Tynor Weight Cuff Measurements
Sizes Available: 1/2 Kg / 1Kg / 2 Kg
good review of the impact of ketones on TBI. The authors conclude that precursors to ketones may be the right approach to treatment. This would be MCT's and ketones.
One of the first studies to look at PCS found that 42% of soldiers produced abnormally low hormone production following TBI one year after the injury. This study highlights the potential pituitary dysfunction that can result from TBI.
Tynor Chest Binder
Chest Binder is applied to the thoracic region to compress and bind the rib cage and provide splinting to the sternum while allowing sufficient flexibility for comfortable breathing.
Anatomic chest pad.
Controlled compression.
Optimum chest splinting.
Soft feel.
Tynor Chest Binder Features
50 mm thick PUF pad hold and binds the fractured sternum without compromising
on patient comfort.
Strong elastic band gives good grip and helps in equidistribution of pressure.
Reduces post operative pain and discomfiture.
Facilitates phlegm expulsion after cardio thoracic surgery.
Tynor Chest Binder Measurements
Measure circumference around the chest.
Good discussion on chronic traumatic encephalopathy. CTE is a condition found in the military and sports related head trauma. This is usually the result of low, repetitive impact injuries to the brain. Though, genetic susceptibility is discussed as well.